Water → HCID 117974495, compound

Participants

Reaction Steps

0.11 g of sodium hydride (60%) was added to a solution of 0.65 g of 2-(3-bromothiophen-2-yl)-5-(trifluoromethyl)benzothiazole and 0.15 ml of ethanethiol in NMP 6 ml 0° C., and the mixture was stirred at room temperature for 1 hour. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with a 10% aqueous hydrochloric acid solution and a saturated aqueous salt solution and dried over anhydrous sodium sulfate, then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.61 g of 2-(3-ethylthiothiophen-2-yl)-5-(trifluoromethyl)benzothiazole (Compound of Present Invention (37)).

Provenance & Evidence