HCID 22026369, compound → HCID 70663095, compound

Participants

Reaction Steps

A mixture of 1800 mg of 10% Pd/C and 390 ml of ethyl acetate is stirred at room temperature under hydrogen atmosphere for 30 minutes. A solution of the compound of Example 41 (800 mg) in 10 ml of ethyl acetate is introduced with a syringe, and stirring is continued under hydrogen atmosphere. At time points of 1 hour 20 minutes, 2 hour 40 minutes, 4 hour and 5 hour 35 minutes further amounts of 1800 mg 10% Pd/C each are added. After a total reaction time of 6 hours 50 minutes, the mixture is filtered through celite and stripped of the solvents to obtain a residue which is subjected to chromatography thrice over SiO2 using toluene/t-butyl methyl ether (17/1). The title compound is obtained as a foam, having characterization data as indicated below.

Provenance & Evidence