Cesium carbonate → HCID 89826327, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 200 mg (1.60 mmol) 1H-pyrrole-2-carboxylic acid methyl ester and 1.56 g (4.79 mmol) cesium carbonate in 3 ml DMF is heated to 50° C. under stirring. Then a solution of 488 mg (1.60 mmol) 1-(4-benzyloxy-phenyl)-2-bromo-ethanone in 1 ml DMF is added within 3 minutes. The reaction mixture is stirred for 18 hours at 50° C. The reaction mixture is filtered with suction and the filtrate is evaporated. The residue is crystallized from diethyl ether to give 1-[2-(4-benzyloxy-phenyl)-2-oxo-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester as beige crystals; HPLC/MS 2.51 min (A), [M+H] 350.

Provenance & Evidence