Ammonia → HCID 71765382, compound

Participants

Reaction Steps

A suspension of 100 mg (0.286 mmol) 1-[2-(4-benzyloxy-phenyl)-2-oxo-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester in a 7 M solution of ammonia in methanol is irradiated in a microwave apparatus at 90° C. for 18 h. The reaction mixture is cooled to room temperature and evaporated. The residue is chromatographed on a silica gel column with petrolether/ethylacetate as eluent to give 3-(4-benzyloxy-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one as beige crystals; HPLC/MS 2.26 min (A), [M+H] 317.

Provenance & Evidence