Cesium carbonate → HCID 89826318, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.15 g (9.19 mmol) 1H-pyrrole-2-carboxylic acid methyl ester and 2.70 g (10.1 mmol) 2-bromo-(1-(4-trifluoromethyl-phenyl)-ethanone in 20 ml acetonitrile is treated with 3.30 g (10.1 mmol) cesium carbonate. The resulting suspension is stirred at 35° C. for 18 hours. The reaction mixture is filtered and the filtrate is evaporated. The residue is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent to give 1-[2-oxo-2-(4-trifluoromethyl-phenyl)-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester as yellow oil; HPLC/MS 2.52 (A), [M+H] 312.

Provenance & Evidence