Ammonium Acetate → HCID 71765426, compound

Participants

Reaction Steps

A solution of 106 mg (0.34 mmol) 1-[2-oxo-2-(4-trifluoromethyl-phenyl)-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester and 789 mg (10.2 mmol) ammonium acetate in 2 ml acetic acid is heated to 80° C. under stirring. The mixture is stirred at this temperature for 5 hours and then cooled to room temperature. The mixture is partitioned between THF and saturated sodium chloride solution. The organic phase is washed two times with 25% aqueous ammonia and two times with saturated sodium chloride solution. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent to give 3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one as colourless crystals; HPLC/MS 2.11 (A), [M+H] 279;

Provenance & Evidence