HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 71765536, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 89826348 | HCID 89826348 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 71765536 | HCID 71765536 | — |
Reaction Steps
82 mg (0.252 mmol) 2-Hydroxymethyl-6-(4-trifluoromethoxy-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one are treated with thionyl chloride in dichloromethane similar to WO2010/043676 (example G02) to give 2-chloromethyl-6-(4-trifluoromethoxy-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one as pale pink crystals; HPLC/MS 1.91 min (C), [M+H] 344;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120805B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-12ded8ce0daa42f0864b7342297b9c15 |
| Source note | uspto-grants-2015_09 |