Phosphorus tribromide → HCID 71765539, compound

Participants

Reaction Steps

To a suspension of 142 mg (0.445 mmol) 6-(4-bromo-phenyl)-2-hydroxymethyl-5H-pyrazolo[1,5-a]pyrazin-4-one in 8 ml dichloromethane is added 52 μl (0.56 mmol) phosphorus tribromide. The reaction mixture is stirred for 20 hours at room temperature. The mixture is partitioned between water and dichloromethane. The organic phase is dried over sodium sulfate and evaporated. Purification by preparative HPLC (RP18 silica gel, eluent water/acetonitrile/formic acid) affords 2-bromomethyl-6-(4-bromo-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one as off-white solid; HPLC/MS 2.21 min (A), [M+H] 384.

Provenance & Evidence