HCID 71765539, compound → HCID 71765542, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 64.4 mg (0.168 mmol) bromomethyl-6-(4-bromo-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one in 2.5 ml acetic acid are added 55 mg (0.84 mmol) activated zinc powder. The reaction mixture is stirred at 100° C. for 18 hours. The reaction mixture is allowed to cool to room temperature and partitioned between water and ethylacetate. The organic phase is washed with saturated sodium hydrogen carbonate solution, dried over sodium sulfate and evaporated to afford 6-(4-bromo-phenyl)-2-methyl-5H-pyrazolo[1,5-a]pyrazin-4-one as white solid;

Provenance & Evidence