Acetic Acid → HCID 89826997, compound

Participants

Reaction Steps

To a slurry of 103 mg (0.33 mmol) 3-[4-(1-azido-1-methyl-ethyl)-phenyl]-7-fluoro-2H-pyrrolo[1,2-a]pyrazin-1-one and 90 mg (1.38 mmol) zinc dust in 2 ml THF is added 175 ml (3.1 mmol) acetic acid and the mixture is stirred for 3 hours at room temperature. The suspension is quenched with THF/dichloromethane/ethyl acetate. The mixture is filtered with suction and the residue is washed with methanol. The filtrate is evaporated and the residue is purified by preparative HPLC to afford 3-[4-(1-amino-1-methyl-ethyl)-phenyl]-7-fluoro-2H-pyrrolo[1,2-a]pyrazin-1-one formate salt as white solid; HPLC/MS 1.57 min (B), [M+H] 268;

Provenance & Evidence