Potassium Carbonate → HCID 89826290, compound

Participants

Reaction Steps

1H-Pyrrole-2-carbonitrile (0.84 ml; 9.42 mmol) and 1-{4-[4-(2-bromo-acetyl)phenyl]-piperidin-1-yl}-2,2,2-trifluoro-ethanone (2.74 g; 7.25 mmol) are dissolved in acetone (25 ml). To this clear brown solution potassium carbonate (2 g; 14.49 mmol) is added and the mixture is stirred at room temperature overnight. The reaction mixture is filtered off by suction and washed with acetone. The filtrate is evaporated to dryness. The residue is purified by flash chromatography to afford 1-(2-oxo-2-{4-[1-(2,2,2-trifluoro-acetyl)-piperidin-4-yl]-phenyl}-ethyl)-1H-pyrrole-2-carbonitrile as pale off-white crystals.

Provenance & Evidence