Trifluoroacetic acid → O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Participants

Reaction Steps

To the solid product N-(tert.-butoxycarbonyl)-O-(mesitylsulfonyl)-hydroxylamine (2.1 g, 6.6 mmol) is added trifluoroacetic acid (20 mL) slowly at 0° C. under a nitrogen atmosphere. The reaction mixture is stirred for 30 minutes followed slowly by water (60 mL). The reaction is left at 0° C. for 15 minutes. The solid precipitated is filtered and washed several times with water until the pH of the filtrate was neutral. The white solid (1.4 g, 98%) is dried in the Buchner funnel and used immediately for the next reaction; 1H NMR (400 MHz, DMSO-d6): δ6.73 (s, 2H), 2.48 (s, 6H), 2.15 (s, 3H).

Provenance & Evidence