HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-3,5-dimethoxybenzene → (3,5-Dimethoxy-phenyl)-[8-(3-phenyl-piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-3,5-dimethoxybenzene | HCID 81502 | — |
| Reactant | Tert-butyl 3-phenylpiperazine-1-carboxylate | HCID 2735358 | — |
| Reactant | 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine | HCID 77231010 | — |
| Product | (3,5-Dimethoxy-phenyl)-[8-(3-phenyl-piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-amine | HCID 71721796 | — |
Reaction Steps
8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine and tert-butyl 3-phenyl-piperazine-1-carboxylate were coupled according general procedure 3. The intermediate was isolated and Buchwald Hartwig Amination following general procedure 2 with 1-chloro-3,5-dimethoxy-benzene gave the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-52951bcbac28489b9b3168c0ff860f66 |
| Source note | uspto-grants-2015_09 |