HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-3,5-dimethoxybenzene → (3,5-Dimethoxy-phenyl)-[8-(4-methyl-2-phenyl-piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-3,5-dimethoxybenzene | HCID 81502 | — |
| Reactant | 1-Methyl-3-phenylpiperazine | HCID 2760009 | — |
| Reactant | 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine | HCID 77231010 | — |
| Product | (3,5-Dimethoxy-phenyl)-[8-(4-methyl-2-phenyl-piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-amine | HCID 89767138 | — |
Reaction Steps
8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine and 1-methyl-3-phenyl-piperazine are coupled according general procedure 3. The intermediate is isolated and Buchwald Hartwig Amination following general procedure 2 with 1-chloro-3,5-dimethoxy-benzene gives the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-0aa383ca693b4201bfa2d4a6f9d7f054 |
| Source note | uspto-grants-2015_09 |