1-Bromo-4-tert-butylbenzene → (4-tert-butyl-phenyl)-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-amine

HRID 2273007Notes

Reaction equation

HRID 2273007 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]3[N:9]([N:13]=[C:14]([NH2:16])[N:15]=3)[CH:10]=[CH:11][N:12]=2)[CH:4]=[N:3]1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([CH3:27])([CH3:26])[CH3:25])=[CH:20][CH:19]=1>>[C:24]([C:21]1[CH:22]=[CH:23][C:18]([NH:16][C:14]2[N:15]=[C:8]3[C:7]([C:5]4[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=4)=[N:12][CH:11]=[CH:10][N:9]3[N:13]=2)=[CH:19][CH:20]=1)([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 775951-Bromo-4-tert-butylbenzeneHCID 665833238-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

Product 1

HCID 89767222(4-tert-butyl-phenyl)-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-amine

Procedure

8-(1-Methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine, as described earlier, is coupled with 1-bromo-4-tert-butyl-benzene according to general procedure 2.

Sources & evidence

ORD record
ord-e6c73ba086814aa8b4a41fd2b518c123
Source dataset
uspto-grants-2015_09
Patent number
US09120804B2

Reaction notes

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