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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2273010Generated: October 29, 2026

1-(p-Chlorophenyl)cyclopropanecarbonitrile → 1-{4-[8-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

https://huagongshe.com/reaction/2273010

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(p-Chlorophenyl)cyclopropanecarbonitrileHCID 98666—
Reactant4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 2774010—
Reactant8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amineHCID 77231010—
Product1-{4-[8-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrileHCID 71721822—

Reaction Steps

8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine is reacted first with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole using general procedure 1 and then with 1-(4-chlorophenyl)-1-cyclopropanecarbonitrile following general procedure 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09120804B2
Source datasetuspto-grants-2015_09
ORD IDord-ec4e3d00efad44f6a82af7f20c439755
Source noteuspto-grants-2015_09