6-chloro-3,3-dimethyl-2,3-dihydro-1H-indol-2-one → 3,3-dimethyl-6-[8-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one
Reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]3[N:8]([N:12]=[C:13]([NH2:15])[N:14]=3)[CH:9]=[CH:10][N:11]=2)[CH:3]=[N:2]1.Cl[C:17]1[CH:25]=[C:24]2[C:20]([C:21]([CH3:28])([CH3:27])[C:22](=[O:26])[NH:23]2)=[CH:19][CH:18]=1>>[CH3:27][C:21]1([CH3:28])[C:20]2[C:24](=[CH:25][C:17]([NH:15][C:13]3[N:14]=[C:7]4[C:6]([C:4]5[CH:5]=[N:1][NH:2][CH:3]=5)=[N:11][CH:10]=[CH:9][N:8]4[N:12]=3)=[CH:18][CH:19]=2)[NH:23][C:22]1=[O:26]Participants
3
Procedure
8-(1H-Pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine synthesized as descried earlier, is reacted with 6-chloro-3,3-dimethyl-1,3-dihydro-indol-2-one under Buchwald Hartwig conditions using general procedure 2.
Sources & evidence
- ORD record
- ord-19417dbf0ae94de69b93a8f1f0f0beba
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120804B2
Reaction notes
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