HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-Trimethylpyrazole-4-boronic acid → 3,3-dimethyl-6-[8-(1,3,5-trimethyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-Trimethylpyrazole-4-boronic acid | HCID 11171100 | — |
| Reactant | 6-chloro-3,3-dimethyl-2,3-dihydro-1H-indol-2-one | HCID 58398957 | — |
| Reactant | 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine | HCID 77231010 | — |
| Reactant | 8-(1,3,5-Trimethylpyrazol-4-yl)[1,2,4]triazolo[1,5-a]pyrazin-2-amine | HCID 117818213 | — |
| Product | 3,3-dimethyl-6-[8-(1,3,5-trimethyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one | HCID 89769053 | — |
Reaction Steps
8-(1,3,5-Trimethylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine, synthesized by reaction of 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine with (1,3,5-trimethylpyrazol-4-yl)boronic acid following procedure 1, is coupled with 6-chloro-3,3-dimethyl-1,3-dihydro-indol-2-one under Buchwald Hartwig conditions using general procedure 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-ef91511b78254e97933eed1546f142fe |
| Source note | uspto-grants-2015_09 |