HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-2,3-dione, 6-bromo- → 3-hydroxy-3-methyl-6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-2,3-dione, 6-bromo- | HCID 95716 | — |
| Reactant | 6-Bromo-3-hydroxy-3-methylindolin-2-one | HCID 66580258 | — |
| Reactant | 8-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine | HCID 66583323 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Product | 3-hydroxy-3-methyl-6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1,3-dihydro-indol-2-one | HCID 71721826 | — |
Reaction Steps
8-(1-Methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine is reacted with 6-bromo-3-hydroxy-3-methyl-1,3-dihydro-indol-2-one, available via addition of methymagnesiumbromide to 6-bromo-Isatin, to give the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1cf3d0cc6dd14e56ae9cda8013078508 |
| Source note | uspto-grants-2015_09 |