HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-Pyrrolidinol → 6-[8-((R)-3-hydroxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-3,3-dimethyl-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-Pyrrolidinol | HCID 2759337 | — |
| Reactant | 6-chloro-3,3-dimethyl-2,3-dihydro-1H-indol-2-one | HCID 58398957 | — |
| Reactant | 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine | HCID 77231010 | — |
| Reactant | (R)-1-(2-Amino-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-pyrrolidin-3-ol | HCID 89767228 | — |
| Product | 6-[8-((R)-3-hydroxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-3,3-dimethyl-1,3-dihydro-indol-2-one | HCID 89767283 | — |
Reaction Steps
(R)-1-(2-Amino-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-pyrrolidin-3-ol, synthesized by reaction of 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine and (R)-pyrrolidin-3-ol following general procedure 3, is coupled with 6-chloro-3,3-dimethyl-1,3-dihydro-indol-2-one under Buchwald Hartwig conditions using general procedure 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1c78da2f5b5b4a458f829131bd007fba |
| Source note | uspto-grants-2015_09 |