3-Hydroxyazetidine → 6-[8-(3-Hydroxy-azetidin-1-yl)-(1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-3,3-dimethyl-1,3-dihydro-indol-2-one

Participants

Reaction Steps

1-(2-Amino-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-azetidin-3-ol, available by nucleophilic substitution of 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine with azetidin-3-ol using general procedure 3, is reacted under amination conditions described in general procedure 2 with 6-chloro-3,3-dimethyl-1,3-dihydro-indol-2-one giving the title compound as a solid.

Provenance & Evidence