HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chlorophenol → 2,2-dimethyl-6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chlorophenol | HCID 7265 | — |
| Reactant | 2-Bromo-2-methylpropionyl bromide | HCID 88685 | — |
| Reactant | 6-Chloro-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one | HCID 10560458 | — |
| Reactant | 8-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine | HCID 66583323 | — |
| Product | 2,2-dimethyl-6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-4H-benzo[1,4]oxazin-3-one | HCID 89776003 | — |
Reaction Steps
8-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine is coupled with 6-chloro-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one, available by reaction of 2-amino-4-chlorphenol with 2-bromo-2-methyl-propanoyl bromide under basic conditions, using general procedure 2 gave the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-22d96d872fa9480d9c77dd57330278ff |
| Source note | uspto-grants-2015_09 |