1H-Indole-2,3-dione, 6-bromo- → HCID 89767111, compound

Participants

Reaction Steps

Addition of isopropylmagnesiumchloride to 6-bromoisatin at −78° C. in THF gives after usual workup 6-bromo-3-hydroxy-3-isopropyl-1,3-dihydro-indol-2-one which is reacted with 8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine using general procedure 2 to give the title compound as a solid.

Provenance & Evidence