Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Tert-butyl 3-oxopyrrolidine-1-carboxylate | HCID 471360 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18442718 | HCID 18442718 | — |
Reaction Steps
3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (1 eq.) and potassium cyanide (1.3 eq) are dissolved in ethanol before ammonium carbonate (8 eq.) in water is added. The mixture is heated to 90° C. for 2 h and monitored by LCMS. Upon completion, the solvent is removed in vacuum. The residue is diluted with water and the product filtered off. Boc-deprotection under standard conditions gives the desired hydantoine as HCl-salt ready for further modifications.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09120804B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-a9999800bf7e470996918b440e05c1d7 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
