HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2273021Generated: October 30, 2026
Ethanol → 2,5,7-Triazaspiro[3.4]octane-6,8-dione
https://huagongshe.com/reaction/2273021
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | 3-Oxo-azetidine-1-carboxylic acid tert-butyl ester | HCID 1519404 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,5,7-Triazaspiro[3.4]octane-6,8-dione | HCID 66600720 | — |
Reaction Steps
3-Oxo-azetidine-1-carboxylic acid tert-butyl ester (1 eq.) and potassium cyanide (1.3 eq) are dissolved in ethanol before ammonium carbonate (8 eq.) in water is added. The mixture is heated to 90° C. for 19 h and monitored by LCMS. Upon completion, the solvent is removed in vacuum. The residue is diluted with water and the product filtered off. Boc-deprotection under standard conditions gives the desired hydantoine as HCl-salt ready for further modifications.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09120804B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-350c788c2115403eb7d378c904a62964 |
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| Source note | uspto-grants-2015_09 |
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