HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2,2,2-trifluoro-1-{6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1H-indol-3-yl}-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 6-Bromoindole | HCID 676493 | — |
| Reactant | 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone | HCID 12706370 | — |
| Reactant | 8-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine | HCID 66583323 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,2,2-trifluoro-1-{6-[8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-1H-indol-3-yl}-ethanone | HCID 89769067 | — |
Reaction Steps
8-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine is reacted with 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoro-ethanone, available by reaction of 6-bromo-1H-indole (1 eq.) with TFA (1.6 eq) in DMF at 120° C. for 1 h, under conditions described in general procedure 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-06106bba795a427e968dd324c580e0b4 |
| Source note | uspto-grants-2015_09 |