HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone → 2-(6-bromo-1H-indol-3-yl)-1,1,1-trifluoro-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone | HCID 12706370 | — |
| Reactant | HCID 178418332 | HCID 178418332 | — |
| Product | 2-(6-bromo-1H-indol-3-yl)-1,1,1-trifluoro-propan-2-ol | HCID 117818272 | — |
Reaction Steps
1-(6-Bromo-1H-indol-3-yl)-2,2,2-trifluoro-ethanone is treated with methylmagnesiumchloride at −78° C. to rt to obtain 2-(6-bromo-1H-indol-3-yl)-1,1,1-trifluoro-propan-2-ol, which is coupled with 8-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine following general procedure 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120804B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-9b04861a420040858f8c385e4c2eeafb |
| Source note | uspto-grants-2015_09 |