HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 178480701, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 4-Chloro-2-{[(4-fluorophenyl)sulfonyl]methyl}-6-(4-methylpiperazin-1-yl)aniline | HCID 44242922 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178480701 | HCID 178480701 | — |
Reaction Steps
A solution of NaNO2 (22.0 mg) in water at 0° C. is treated dropwise with a solution of 4-chloro-2-{[(4-fluorophenyl)sulfonyl]methyl}-6-(4-methylpiperazin-1-yl)aniline (102.2 mg, 0.25 mmol) in 1M HCl, allowed to warm to room temperature over a 2 h period, treated with saturated Na2CO3 to pH>10 and filtered. The filtercake is washed with water and dried in vacuo to give the title compound, identified by mass spectral and NMR analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560470B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-caf9c8faa2134e6abf81d500f803933a |
| Source note | uspto-grants-2009_07 |