HCID 178451925, compound → HCID 178451923, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl 2-(4-(4-(3-(benzyloxycarbonylamino) cyclobutyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (A8) (449 mg, 0.87 mmol) in methanol (10 mL) was added 10% Pd/C (50 mg) and the mixture was stirred overnight under H2 atmosphere in a balloon. The mixture was filtrated and concentrated to obtain the crude product (S)-tert-butyl 2-(4-(4-(3-aminocyclobutyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (A9) (330 mg, 99% yield) without further purification.

Provenance & Evidence