Hydrochloric Acid → HCID 178419939, compound

Participants

Reaction Steps

To a solution of A5 (19.2 g) in dichloromethane (500 mL) at −20° C. was added acetyl chloride (16.8 mL), followed by aluminum chloride (43 g). The reaction was allowed to warm up to rt. After overnight stirring, the reaction was poured into a mixture of ethyl acetate (800 mL), 1M HCl (800 mL) along with some ice. After separating the organic layer, the aqueous layer was extracted with ethyl acetate (3×300 mL). The combined organic layers were washed with brine, H2O, dried over Na2SO4, filtered, and concentrated to afford A6 (24 g), which was used for next reaction without further purification.

Provenance & Evidence