HCID 178451925, compound → HCID 178451923, compound

Participants

Reaction Steps

To a suspension of A8 (17.8 g) in acetic acid (250 mL), hydrogen bromide (33% in acetic acid, 25 mL) was added dropwise at rt. After stirring for an additional hour, the reaction was filtered though a pad of CELITE™454, washed with ethyl acetate, concentrated to afford the crude product, which was purified by silica gel flash column chromatography (Hexanes/EtOAc=3/1 (v/v)) to provide A9 (18.5 g).

Provenance & Evidence