Acetic Acid → HCID 71008487, compound

Participants

Reaction Steps

To a mixture consisting of Compound 28A in methanol is added potassium carbonate (10 molar equivalents) and the mixture stirred for 30 minutes at room temperature. Acetic acid is added to neutral pH and the solution is stirred 30 minutes. Solvent is evaporated and the mixture is partitioned between ethyl acetate and water. The organics are washed with brine, dried and evaporated. The residue is chromatographed on silica gel to obtain the title intermediate.

Provenance & Evidence