Thionyl Chloride → 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonyl chloride
Reaction equation
[Cl:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([Cl:11])[N:5]=[C:4]([S:12][CH3:13])[N:3]=1.S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[C:7]([C:8]([Cl:16])=[O:9])=[C:6]([Cl:11])[N:5]=[C:4]([S:12][CH3:13])[N:3]=1Participants
3
Procedure
10 g of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylic acid (41.83 mmol) are placed in 61 ml of thionyl chloride (836.54 mmol) with stirring. After 18 hours at 80° C., the thionyl chloride is evaporated off and the residue is taken up twice with 15 ml of toluene and concentrated to give 10.77 g of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carbonyl chloride.
Workup
- customthe thionyl chloride is evaporated off
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-cfe28dad7ac0483abe7c5af9669e7502
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120812B2
Reaction notes
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