HCID 75480723, compound → 5-(Pyrrolidin-1-yl)pyridin-2-amine

HRID 2273085Notes

Reaction equation

HRID 2273085 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:6][N:5]=1)([O-])=O>[Pd]>[N:10]1([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[N:5][CH:6]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 1

HCID 75480723HCID 75480723, compound

Product 1

HCID 167793145-(Pyrrolidin-1-yl)pyridin-2-amineYield 92.8%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

410 mg (2.12 mmol) of the product obtained in step 25.1 are hydrogenated in the presence of 10% Pd/C at atmospheric pressure at 35° C. The solution obtained is evaporated under reduced pressure to give 321 mg of 5-pyrrolidin-1-ylpyridin-2-ylamine.

Workup

  1. customThe solution obtained
  2. customis evaporated under reduced pressure

Sources & evidence

ORD record
ord-8d3f3af05ba7426988771a7bdc2ec61c
Source dataset
uspto-grants-2015_09
Patent number
US09120812B2

Reaction notes

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