2-Chloro-5-nitropyridine → HCID 32810003, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1 g (6.18 mmol) of 2-chloro-5-nitropyridine and 1.31 g (12.36 mmol) of (S)-3-methylmorpholine is heated in a Biotage microwave machine for 1 hour at 150° C. The reaction medium is taken up in MeOH and then evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0 v/v) up to (95/5 v/v) to give 1.35 g of (S)-3-methyl-4-(5-nitropyridin-2-yl)morpholine.

Provenance & Evidence