HCID 32810003, compound → HCID 89714726, compound

HRID 2273090Notes

Reaction equation

HRID 2273090 reaction equation
[CH3:1][C@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=1>[Pd]>[CH3:1][C@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 32810003HCID 32810003, compound

Product 1

HCID 89714726HCID 89714726, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1.35 g (6 mmol) of the product obtained in step 29.1 are hydrogenated in the presence of 10% Pd/C at atmospheric pressure at 50° C. The solution obtained is evaporated under reduced pressure to give 1.17 g of 6-((S)-3-Methylmorpholin-4-yl)pyridin-3-ylamine.

Workup

  1. customThe solution obtained
  2. customis evaporated under reduced pressure

Sources & evidence

ORD record
ord-345f239d56734529aeb1a5e7eefcf37c
Source dataset
uspto-grants-2015_09
Patent number
US09120812B2

Reaction notes

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