HCID 86731612, compound → 2-Methyl-D-proline methyl ester hydrochloride

Participants

Reaction Steps

To a solution of (7aR)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (D2) (0.11 g, 0.42 mol) in dry MeOH (2 ml), HCl 1M sol in MeOH (0.3 ml, 0.85 mol) was added and the mixture refluxed under a constant current of nitrogen for 1 h. Solvent was evaporated to afford the title compound (D3) 60 mg.

Provenance & Evidence