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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2273096Generated: November 1, 2026

(2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acid → HCID 86731615, compound

https://huagongshe.com/reaction/2273096

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acidHCID 688618—
Reactant(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 57462942—
ProductHCID 86731615HCID 8673161595.2%

Reaction Steps

The title compound (D5) (405 mg) was prepared according to the general procedure for amides preparation starting from (R)-1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (250 mg, available from Sigma Aldrich #516341), and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride (235 mg). Reaction time: 18 hrs.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09120824B2
Source datasetuspto-grants-2015_09
ORD IDord-4da07142550e4068bf084f5fec9ed0c2
Source noteuspto-grants-2015_09