HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 71204758, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | 2-Methyl-D-proline methyl ester hydrochloride | HCID 71306205 | — |
| Product | HCID 71204758 | HCID 71204758 | 47.3% |
Reaction Steps
The title compound (D10) (47 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from (R)-methyl 2-methylpyrrolidine-2-carboxylate hydrochloride (D3) (60 mg, 0.33 mmol) and 3-(Trifluoromethyl)benzyl bromide (0.076 ml, 0.50 mmol). (Na2CO3: 3 eq; Reaction time: 8 hrs; 60° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120824B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-aabd669491654a2daad56703414aad3d |
| Source note | uspto-grants-2015_09 |