tert-Butyl carbamate → HCID 71204683, compound

HRID 2273101Notes

Reaction equation

HRID 2273101 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]([NH:21][C:22]([C@H:24]2[CH2:29][CH2:28][CH2:27][CH2:26][N:25]2C(OC(C)(C)C)=O)=[O:23])[CH3:20])=[CH:15][CH:14]=1)=[O:12]>>[NH:25]1[CH2:26][CH2:27][CH2:28][CH2:29][C@@H:24]1[C:22]([NH:21][C@H:19]([C:16]1[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=1)[CH3:20])=[O:23]

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 86731615HCID 86731615, compound

Product 1

HCID 71204683HCID 71204683, compoundYield 95%

Procedure

The title compound (D12) (286 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (R)-tert-butyl 2-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)piperidine-1-carboxylate (D5) (405 mg).

Sources & evidence

ORD record
ord-1e2b888c894542daa0a16d3dfdb00aba
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

Loading…