tert-Butyl carbamate → HCID 71204684, compound

HRID 2273102Notes

Reaction equation

HRID 2273102 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([NH:22][C:23]([C@H:25]3[CH2:30][CH2:29][CH2:28][CH2:27][N:26]3C(OC(C)(C)C)=O)=[O:24])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)=[O:12]>>[NH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][C@@H:25]1[C:23]([NH:22][C:19]1([C:16]2[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=2)[CH2:21][CH2:20]1)=[O:24]

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 86731619HCID 86731619, compound

Product 1

HCID 71204684HCID 71204684, compoundYield 100.3%

Procedure

The title compound (D13) (490 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (R)-tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate (D6) (650 mg).

Sources & evidence

ORD record
ord-bc8b212382fd4c179f17ac5ae50c0106
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

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