HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 71204757, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | HCID 71204683 | HCID 71204683 | — |
| Product | HCID 71204757 | HCID 71204757 | 28.7% |
Reaction Steps
The title compound (D22) (18 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-((S)-1-((R)-piperidine-2-carboxamido)ethyl)benzoate (D12) (40 mg, 0.14 mmol) and 3-(trifluoromethyl)benzyl bromide (0.031 ml, 0.21 mmol). (Na2CO3: 2.5 eq; reaction time: 4 hrs; 60° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120824B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-fcb65b6386c745d08d950cc14ea6cb76 |
| Source note | uspto-grants-2015_09 |