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HRID2273112

反应详情

EQUATION

反应方程式

HRID 2273112 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：Cc1cccc(CBr)c1
HCID12099

Benzene, 1-(bromomethyl)-3-methyl-

C8H9Br

结构：COC(=O)c1ccc(C2(NC(=O)[C@H]3CCCCN3)CC2)cc1
HCID71204684

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(C2(NC(=O)[C@H]3CCCCN3Cc3cccc(C)c3)CC2)cc1
HCID71204764

未命名化合物

收率 96.9%

PROCEDURE

实验过程

The title compound (D27) (63 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from (R)-methyl 4-(1-(piperidine-2-carboxamido)cyclopropyl)benzoate (D13) (50 mg, 0.16 mmol) and 3-methyl benzyl bromide (0.033 ml, 0.25 mmol). (Na2CO3: 2.5 eq; reaction time: 6 hrs; 60° C.)