HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → (R)-methyl 4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Fluorobenzyl bromide | HCID 68007 | — |
| Reactant | HCID 71204684 | HCID 71204684 | — |
| Product | (R)-methyl 4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate | HCID 71204706 | 94.4% |
Reaction Steps
The title compound (D28) (62 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from (R)-methyl 4-(1-(piperidine-2-carboxamido)cyclopropyl)benzoate (D13) (50 mg, 0.16 mmol) and 3-fluoro benzyl bromide (0.03 ml, 0.25 mmol). (Na2CO3: 2.5 eq; reaction time: 6 hrs; 60° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120824B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-6d09fec9417545818655f64c17bfc262 |
| Source note | uspto-grants-2015_09 |