4-Fluoro-3-(trifluoromethyl)benzaldehyde → HCID 71204754, compound

HRID 2273115Notes

Reaction equation

HRID 2273115 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]1[C:7]([NH:9][C:10]1([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH2:12][CH2:11]1)=[O:8].[F:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][C:25]=1[C:32]([F:35])([F:34])[F:33]>>[F:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][C@@H:2]2[C:7]([NH:9][C:10]2([C:13]3[CH:14]=[CH:15][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:21][CH:22]=3)[CH2:12][CH2:11]2)=[O:8])=[CH:26][C:25]=1[C:32]([F:33])([F:34])[F:35]

Participants

3

Reactant 2

HCID 5222694-Fluoro-3-(trifluoromethyl)benzaldehydeHCID 71204684HCID 71204684, compound

Product 1

HCID 71204754HCID 71204754, compoundYield 56.3%

Procedure

The title compound (D30) (35 mg) was prepared according sperimental procedure described in description 29 starting from (R)-methyl 4-(1-(piperidine-2-carboxamido)cyclopropyl)benzoate (D13) (40 mg, 0.13 mmol) and 4-fluoro-3-(trifluoromethyl)benzaldehyde (0.02 ml, 0.16 mmol)

Sources & evidence

ORD record
ord-6007b42f4f9e4c888d82054ba19e174e
Source dataset
uspto-grants-2015_09
Patent number
US09120824B2

Reaction notes

Loading…