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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2273134Generated: October 30, 2026

Lithium hydroxide, monohydrate → (R)-4-(1-(1-(4-fluoro-3-methylbenzyl)piperidine-2-carboxamido)cyclopropyl)benzoic acid

https://huagongshe.com/reaction/2273134

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium hydroxide, monohydrateHCID 168937—
Reactant(R)-methyl 4-(1-(1-(4-fluoro-3-methylbenzyl)piperidine-2-carboxamido)cyclopropyl)benzoateHCID 71204755—
Product(R)-4-(1-(1-(4-fluoro-3-methylbenzyl)piperidine-2-carboxamido)cyclopropyl)benzoic acidHCID 7118619131.7%

Reaction Steps

The title compound (E12) (10.1 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 4-(1-(1-(4-fluoro-3-methylbenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D29) (33 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09120824B2
Source datasetuspto-grants-2015_09
ORD IDord-601c8237ea32448199d63925c2f3dfeb
Source noteuspto-grants-2015_09