3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylic acid → HCID 178487791, compound

HRID 2273207Notes

Reaction equation

HRID 2273207 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH:23][C:24](=O)[OH:25])[CH2:19][CH2:18]3)[CH2:7][C:6]2=1.[O:27]=[C:28]1[CH2:33][S:32][C:31]2[CH:34]=[CH:35][C:36](C(O)=O)=[N:37][C:30]=2[NH:29]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH:23][C:24]([C:36]4[CH:35]=[CH:34][C:31]5[S:32][CH2:33][C:28](=[O:27])[NH:29][C:30]=5[N:37]=4)=[O:25])[CH2:19][CH2:18]3)[CH2:7][C:6]2=1

Participants

3

Reactant 2

HCID 218737873-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylic acidHCID 178487792HCID 178487792, compound

Product 1

HCID 178487791HCID 178487791, compound

Procedure

The titled compound is prepared as a white lyophilizated powder following Scheme 6 and in analogy to Example 1 using [trans-4-(6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-yl)-cyclohexyl]-carbamic acid text-butyl ester and 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-7990c547bd9d4b4a8bf89da60648f972
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

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