HRID2273216

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID760993

3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid

C9H7NO3S

反应SMILES：COc1ccc2ncc3c(c2n1)N(C)C(c1ccc(NC(=O)OC(C)(C)C)cn1)CO3

HCID67247488

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc2ncc3c(c2n1)N(C)C(c1ccc(NC(=O)c2ccc4c(c2)NC(=O)CS4)cn1)CO3

HCID86671534

未命名化合物

PROCEDURE

实验过程

The titled compound is prepared as a light yellow lyophilizated powder following Scheme 5 and in analogy to Example 1 using [6-(6-methoxy-4-methyl-3,4-dihydro-2H-1-oxa-4,5,9-triaza-phenanthren-3-yl)-pyridin-3-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid acid as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-80224b43ba204421bc052c2e89fa8c51
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09120822B2
来源说明: uspto-grants-2015_09

反应SMILES

C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][C:11]([CH:14]2[N:27]([CH3:28])[C:26]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([O:29][CH3:30])[N:24]=4)[N:19]=[CH:18][C:17]=3[O:16][CH2:15]2)=[CH:12][CH:13]=1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40]([C:43]([OH:45])=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[CH3:30][O:29][C:23]1[N:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][C:17]1[O:16][CH2:15][CH:14]([C:11]3[N:10]=[CH:9][C:8]([NH:7][C:43]([C:40]4[CH:41]=[CH:42][C:36]5[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)=[O:45])=[CH:13][CH:12]=3)[N:27]([CH3:28])[C:26]2=1