3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487798, compound

HRID 2273231Notes

Reaction equation

HRID 2273231 reaction equation
C([O:5][C:6](=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH:14]2[CH:27]([OH:28])[C:26]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([O:29][CH3:30])[CH:24]=4)[N:19]=[CH:18][C:17]=3[O:16][CH2:15]2)[CH2:10][CH2:9]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[OH:28][CH:27]1[C:26]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:29][CH3:30])[CH:24]=3)[N:19]=[CH:18][C:17]=2[O:16][CH2:15][CH:14]1[C@H:11]1[CH2:10][CH2:9][C@H:8]([NH:7][C:6]([C:40]2[CH:41]=[CH:42][C:36]3[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=3[CH:39]=2)=[O:5])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178487799HCID 178487799, compound

Product 1

HCID 178487798HCID 178487798, compound

Procedure

The titled compound is prepared as a white lyophilizated powder following Scheme 6 and in analogy to Example 15 using [trans-4-(4-hydroxy-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-yl)-cyclohexyl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-841078dcc34a40aca78f7c4c7a4fd92d
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

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