3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487822, compound

HRID 2273242Notes

Reaction equation

HRID 2273242 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[NH:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH2:23])[CH2:19][CH2:18]3)[O:7][C:6]2=1.[O:24]=[C:25]1[NH:30][C:29]2[CH:31]=[C:32]([C:35](O)=[O:36])[CH:33]=[CH:34][C:28]=2[S:27][CH2:26]1>>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[NH:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH:23][C:35]([C:32]4[CH:33]=[CH:34][C:28]5[S:27][CH2:26][C:25](=[O:24])[NH:30][C:29]=5[CH:31]=4)=[O:36])[CH2:19][CH2:18]3)[O:7][C:6]2=1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178487819HCID 178487819, compound

Product 1

HCID 178487822HCID 178487822, compound

Procedure

The titled compound is prepared as a white lyophilizated powder following Scheme 7 and in analogy to Example 1 using trans-4-(6-methoxy-2,3-dihydro-1H-4-oxa-1,5,9-triaza-phenanthren-3-yl)-cyclohexylamine and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-aecbe3b198a44feda2750c1760125585
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

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